The proposed Transatlantic Trade and Investment Partnership (TTIP) is unprecedented in scope and ambition. When concluded, the TTIP will become the world’s largest free trade pact. All the economic analysis points to big economic gains from a trans-Atlantic free trade area, but there will, of course, be winners and losers. If Small and Medium Sized Businesses (SMEs) are the backbone of the European and American economies, where do they stand and who speaks for them in the transatlantic negotiations? Representatives for small businesses as well as regulators from both the United States and the European Union got together to discuss the prospects and challenges for SMEs.